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Life Science Quiz | Applied Genetics, Immunity, Drug Resistance and Human Regulation

1 / 100.0s

Problem 1

Genetically near-identical plants propagated from the same stock are grown for the same length of time. Group A receives ample light, while Group B receives weak light. The groups develop different average stem lengths and leaf colors.

Which conclusion is best supported by this result?

View explanation

A phenotype can be influenced by both genotype and environmental factors. Because the experiment keeps genetic background nearly constant while changing light conditions, the difference shows that environment can affect phenotype. Appearance alone does not establish that the DNA sequence changed or that the observed change will be inherited.

Problem 2

The somatic cells of an organism contain 24 chromosomes. Its normal gametes contain 12 chromosomes, and fertilization of two gametes produces a zygote with 24 chromosomes.

Which mechanism best explains why chromosome number is generally maintained across generations?

View explanation

Meiosis produces gametes with one chromosome set from cells that initially have two sets. Fertilization joins two 12-chromosome gametes and restores the total to 24, preventing chromosome number from doubling in each generation. Ordinary mitosis does not halve the number of chromosome sets.

Problem 3

For a fully penetrant trait inherited through a single autosomal recessive locus, both parents are unaffected carriers. Their first child inherited both associated alleles and displays the trait.

What is the probability that a child from the next pregnancy will display the same trait?

View explanation

For an Aa by Aa cross, the possible genotypes in each pregnancy are AA, Aa, Aa and aa. The trait-expressing aa genotype therefore has a probability of one quarter. The first child's outcome does not change which gametes combine at the next fertilization. This probability does not guarantee exactly one affected child in every four children within a family.

Problem 4

A DNA variant that arose after conception is found in cells sampled from one area of an adult's skin. It is not detected in blood cells or germ cells and occurs only in the cell lineage descended from those skin cells.

Which explanation of this variant is most reasonable?

View explanation

A variant that arises after conception outside the germ cells and remains in a limited cell lineage is a somatic variant. It can be passed to descendants of that cell, but it is not ordinarily inherited by the next generation if germ cells do not carry it. Somatic variants also do not invariably cause disease; their effects depend on their location and function.

Problem 5

In a cell, the relevant gene has an intact DNA sequence and produces a normal amount of mature mRNA. However, ribosomes cannot bind to that mRNA, and the corresponding protein is not detected.

Which process is directly disrupted?

View explanation

The presence of a normal amount of mature mRNA indicates that transcription from DNA to RNA has occurred. Ribosomes read the mRNA sequence and join amino acids during translation, so failure to bind directly disrupts translation. DNA replication and meiosis are separate from protein synthesis using this mRNA.

Problem 6

When an animal first receives antigen X, its antibody level rises slowly. After sufficient time, a second exposure to X produces a faster increase, while the response to newly introduced antigen Y remains slow.

Which explanation best accounts for these results?

View explanation

Some cells that recognize X remain as memory cells after the primary response. On re-exposure to X, they can proliferate and begin antibody production more rapidly. The slow response to the new antigen Y shows that immune memory is antigen-specific rather than a universal acceleration of responses to every antigen.

Problem 7

Testing confirms that an upper respiratory infection is caused by a virus and that no secondary bacterial infection is present.

Why would an antibiotic not be expected to treat the infection itself?

View explanation

Antibiotics target bacterial structures and processes, such as bacterial cell-wall synthesis, so they do not act on the virus itself. Antiviral drugs have different targets. An antibiotic may be used for a bacterial secondary infection accompanying a viral illness, but the question explicitly states that no such infection is present.

Problem 8

A culture contains many antibiotic-susceptible bacteria and a small number of bacteria that are already resistant. After an antibiotic is added, most susceptible bacteria die. When the survivors reproduce, resistant bacteria make up most of the population.

Which explanation best describes the rise in the proportion of resistant bacteria?

View explanation

The antibiotic reduces susceptible bacteria, while bacteria that already carry resistance are more likely to survive. As those survivors reproduce, the proportion of resistant bacteria increases. Resistance is a property of the microorganisms, not of the human body, and the antibiotic does not cause all bacteria to intentionally generate the needed mutation.

Problem 9

Identical cultured cells are divided into two groups and placed in media with the same glucose concentration. An appropriate amount of insulin is added to one group. After a fixed time, that group has taken up more glucose into its cells.

Which action of insulin is consistent with this observation?

View explanation

Insulin helps glucose move from the blood into cells, where it can be used for energy. The increased uptake in the insulin-treated group is consistent with this function. Insulin is not made by converting glucose directly into the hormone, and blood-glucose regulation in a whole organism also involves the liver, other hormones and additional factors.

Problem 10

In healthy kidneys, the volume of fluid entering the tubules after glomerular filtration is much greater than the final urine volume. The filtered fluid also contains water and nutrients needed by the body.

Which nephron function best explains this difference?

View explanation

In a nephron, the glomerulus first filters water and small molecules. The tubules then return much of the needed water, minerals and nutrients to the blood, so not all filtered fluid becomes urine. Healthy glomeruli ordinarily retain blood cells and large proteins in the circulation, and reabsorption occurs mainly in the tubules rather than the bladder.